A way to Toggle/Turn off: when making changes to users in the Control Panel,
I have never wanted this option outside of password changes, which is does regardless of this pop-up, and I can't envision ever needing it (I would much rather manually email and explain why/what has changed).

It makes updating profiles tedious, also accidently sending emails to users say that their iSAMS account has changed in some way is prone to panicking users (Which is understandable).